NR ADLI
AU Diringer,H.; Braig,H.R.; Czub,M.
TI Scrapie: a virus-induced amyloidosis of the brain.
QU Ciba Foundation Symposium 1988; 135: 135-45
PT journal article; review; review, tutorial
AB We have studied the pathogenesis of scrapie in hamsters, in particular the increase of infectivity and the formation of scrapie-associated fibrils in relation to clinical disease. The results of such studies after intraperitoneal or intracerebral infection are consistent with the idea that transmissible spongiform encephalopathies are a type of virus-induced, brain-specific amyloidosis. Therefore, an appropriate name for the class of viruses that cause these diseases might be amyloid-inducing viruses.
ZR 24
MH Amyloidosis/*etiology/metabolism/microbiology; Animal; Brain/metabolism; Brain Diseases/*etiology/metabolism/microbiology; Kinetics; Nerve Tissue Proteins/biosynthesis; PrP 27-30 Protein; Prions/pathogenicity; *Scrapie/metabolism/microbiology; Support, Non-U.S. Gov't; Time Factors; Virus Replication
AD Robert Koch-Institut des Bundesgesundheitsamtes, Berlin, Federal Republic of Germany.
SP englisch
PO Niederlande