NR ADNA
AU Doi-Yi,R.; Kitamoto,T.; Ogomori,K.; Mehraein,P.; Tateishi,J.
TI Distribution of prion protein in German patients with Creutzfeldt-Jakob disease is different from that in Japanese patients
QU Acta Neuropathologica 1994 May; 87(5): 481-3
PT journal article
AB We investigated the distribution of prion protein (PrP) in 14 German patients with sporadic Creutzfeldt-Jakob disease (CJD) and compared it with that observed in Japanese patients. Immunohistochemical study revealed diffuse gray matter stainings including synaptic structures in all cases. In addition, 4 patients showed plaque-type deposition which was very rarely observed among sporadic Japanese patients without known mutation of the PrP gene but with valine at codon 129. A higher incidence of PrP plaques in German sporadic CJD may be related to the racial difference in the PrP gene.
IN Die Verteilung der Prionproteine in den anscheinend sporadisch erkrankten Gehirnen deutscher Creutzfeldt-Jakob-PatientInnen unterscheidet sich von der in entsprechenden japanischen Betroffenen gefundenen.
MH Adult; Aged; Caucasoid Race; Comparative Study; Creutzfeldt-Jakob Syndrome/*ethnology/*metabolism/pathology; Germany/ethnology; Human; Immunohistochemistry/methods; Japan/ethnology; Middle Age; Mongoloid Race; Periaqueductal Gray/metabolism; Prions/*metabolism; Synapses/metabolism/ultrastructure; Tissue Distribution
AD Department of Neuropsychiatry, Kumamoto University Medical School, Japan.
SP englisch
PO Deutschland