NR ADNI
AU Dominguez Carmona,M.; Dominguez de la Calle,M.
TI [Spongiform encephalitis]
OT Encefalitis espongiformes
QU Anales de La Real Academia Nacional de Medicina 2001; 118(3): 633-52
PT journal article
AB The authors present a personal interpretation of the pathogeny of prionic processes, showing the role played by heredity. They also present the very surprising fact that a protein codified by a mutant gene can act as transmissible agent in a serious illness opening new chapters to the pathology of a series of important diseases. This is a completely new perspective in the biology.
MH Age Factors; Aged; Animal; Cattle; Codon; Creutzfeldt-Jakob Syndrome/genetics/pathology; Disease Models, Animal; English Abstract; Exons; Genetic Predisposition to Disease; Hamsters; Human; Mice; Mice, Transgenic; Mutation; Polymorphism (Genetics); PrPc Proteins/biosynthesis/*genetics/metabolism; Prion Diseases/*genetics/pathology/transmission; Prions/*genetics; Rats; Scrapie/genetics; Sheep; Synapses/metabolism; Time Factors
SP spanisch
PO Spanien