NR ADPK
AU Draganescu,N.; Girjabu,E.; Antipa,C.; Petrescu,A.; Anghelescu,N.
TI Creutzfeldt-Jakob disease: experimental transmission in the guinea pig.
QU Virologie 1984 Apr-Jun; 35(2): 95-8
PT journal article
AB An experimental disease could be serially propagated in the guinea pig by intracerebral inoculation of cerebrospinal fluid or brain suspensions from 8 patients with Creutzfeldt-Jakob disease (CJD). The disease, characterized by tremor, ataxia and convulsions, appeared after a long incubation period (370-420 days). Microscopic lesions and electron optic features were similar to those described in human CJD and in experimental CJD in the chimpanzee.
MH Animal; Brain/pathology; Creutzfeldt-Jakob Syndrome/cerebrospinal fluid/pathology/*transmission; Disease Models, Animal; Guinea Pigs; Human; Time Factors
SP englisch
PO Rumänien