NR ADQK
AU Duguid,J.; Trzepacz,C.
TI Major histocompatibility complex genes have an increased brain expression after scrapie infection
QU Proceedings of the National Academy of Sciences of the United States of America 1993 Jan 1; 90(1): 114-7
PT journal article
AB We have examined the expression of the major histocompatibility complex (MHC) antigens and related genes in scrapie-infected hamster brain. Both the class I and the class II MHC genes as well as the class II-associated invariant chain were found to have an increased brain expression after scrapie infection. The increased expression of the class I complex was immunohistochemically localized primarily to neurons, though some astrocytes contained much smaller amounts of the class I complex. While there is no detectable immune response to scrapie infection, the possibility that increased MHC expression affords some defense against the scrapie agent is discussed.
IN Mit Scrapie infizierte Hamster zeigten keine Immunantwort, aber die Neuronen ihrer Gehirne verstärkten die Expression der wichtigsten Gewebeverträglichkeitsantigene.
MH Animal; Brain/*immunology/*microbiology; Gene Expression; Genes, MHC Class I; Genes, MHC Class II; Hamsters; Immunohistochemistry; *Major Histocompatibility Complex; Mesocricetus; RNA/genetics/isolation & purification; RNA, Viral/genetics/isolation & purification; Reference Values; Scrapie/*immunology; Support, U.S. Gov't, Non-P.H.S.
AD Department of Medicine, Indiana University School of Medicine, Indianapolis.
SP englisch
PO USA