NR ADTY
AU Epstein,C.J.; Foster,D.B.; DeArmond,S.J.; Prusiner,S.B.
TI Acceleration of scrapie in trisomy 16 - diploid aggregation chimeras
QU Annals of Neurology 1991 Jan; 29(1): 95-7
PT journal article
AB We studied the susceptibility to prion infection of the trisomy 16 - diploid chimeric mouse, a putative model of Down syndrome. When weanling chimeras were inoculated intracerebrally with scrapie prions, the time until appearance of the first symptoms of scrapie was reduced by 17 days (from a mean control time of 153 days) and the time to death was reduced by 30 days (from control time of 170 days). Our results with trisomy 16 chimeras argue that the susceptibility to central nervous system degeneration caused by prions can be modulated by chromosome imbalance.
IN Mäuse mit einer Trisomie 16 erkranken und sterben nach einer Injektion mit Scrapieerregern schneller als normale Mäuse.
MH Animal; Brain/pathology; Chimera; Disease Models, Animal; Disease Susceptibility; Female; Male; Mice; Mice, Inbred BALB C; Scrapie/*genetics/pathology; Support, Non-U.S. Gov't; Support, U.S. Gov't, P.H.S.; Time Factors; *Trisomy
AD Charles J. Epstein, Department of Pediatrics, University of California, San Francisco 94143-0518, CA, USA; Dallas B. Foster, Stanley B. Prusiner, Department of Neurology, University of California, San Francisco, CA, USA; Stephen J. DeArmond, Stanley B. Prusiner, Department of Pathology, University of California, San Francisco, CA, USA; Charles J. Epstein, Stanley B. Prusiner, Department of Biochemistry and Biophysics, University of California, San Francisco, CA, USA
SP englisch
PO USA