NR ADUW
AU Esmonde,T.F.G.; Will,R.G.; Slattery,J.M.; Knight,R.S.G.; Harries-Jones,R.; de Silva,R.N.; Matthews,W.B.
TI Creutzfeldt-Jakob disease and blood transfusion
QU Lancet 1993 Jan 23; 341(8839): 205-7
KI Lancet. 1993 Mar 20; 341(8847): 768. PMID: 8095678 Lancet. 1994 Jan 29; 343(8892): 298-9. PMID: 7905126
PT journal article
AB Epidemiological surveillance of Creutzfeldt-Jakob disease (CJD) in the UK identified 21 patients who had received a blood transfusion and 29 who had donated blood, out of a total of 202 definite and probable cases. This frequency of blood transfusion or donation did not differ from that in age and sex matched controls, and the clinical features in patients with a history of blood transfusion were similar to those of classical CJD and clearly distinct from CJD in recipients of human growth hormone. This evidence does not suggest that blood transfusion is a major risk factor for CJD.
IN Bei heute erkennbar von der Creutzfeldt-Jakob-Krankheit befallenen Patienten in England sollen Bluttransfusionen keine wesentliche Ansteckungsquelle gewesen zu sein. Das Datenmaterial und die Untersuchungsmethoden stellen aber keine überzeugende Grundlage für diese verharmlosende Schlußfolgerung der Autoren dar, die jeder Logik widerspricht.
MH Blood Donors/*statistics & numerical data; Blood Transfusion/*adverse effects; Case-Control Studies; Creutzfeldt-Jakob Syndrome/*epidemiology/etiology/transmission; Death Certificates; England/epidemiology; Growth Hormone/adverse effects; Human; Incidence; Population Surveillance; Prospective Studies; Risk Factors; Support, Non-U.S. Gov't; Time Factors; Wales/epidemiology
AD T. F. G Esmonde, R. G. Will, J. M. Slattery, R. de Silva, Department of Clinical Neurosciences, Western General Hospital, Edinburgh EH4 2XU, UK; R. Knight, W. B. Matthews, University Department of Clinical Neurology, Radcliffe Infirmary, Oxford; R. Harries-Jones, Department of Medicine for the Elderly, Poole Hospital
SP englisch
PO England