NR ADUZ
AU Espana,C.; Gajdusek,D.C.; Gibbs,C.J.Jr.; Osburn,B.I.; Gribble,D.H.; Cardinet,G.H.; Chanock,R.M.
TI Transmission of Creutzfeldt-Jakob disease to the stumptail macaque (Macaca arctoides)
QU Proceedings of the Society for Experimental Biology and Medicine 1975 Jul; 149(3): 723-4
PT journal article
AB The successful transmission of Creutzfeldt-Jakob disease from both affected human and chimpanzee brain to stumptail macaques has been accomplished. The incubation period of 5 yr was the same for both animals; however, the course of the disease was longer in the animal receiving the human brain. In both cases, initial mild symptoms slowly remitted only to reappear some 4 mo later. Muscle biopsies revealed changes suggestive of a mild neuropathy. In addition, there appeared to be an increased ability to incorporate 3H-thymidine in untreated cultures of lymphocytes from peripheral blood.
MH Animal; Astrocytes/pathology; Biopsy; Brain/*pathology; Concanavalin A/pharmacology; Creutzfeldt-Jakob Syndrome/*transmission; Haplorhini; Human; Lectins/pharmacology; Lymphocyte Culture Test, Mixed; Lymphocytes/immunology; *Macaca/blood; Muscles/pathology; Pan troglodytes; Spinal Cord/*pathology; Support, U.S. Gov't, P.H.S.; Time Factors
SP englisch
PO USA