NR ADVU
AU Fagnart,O.C.; van de Wyngaert,F.A.; Mareschal,J.C.; Cornu,G.; Sindic,C.J.
TI Pregnancy-specific beta 1 glycoprotein (SP1) in the cerebrospinal fluid
QU European Neurology 1987; 26(1): 35-9
PT journal article
AB Pregnancy-specific beta 1 glycoprotein (SP1) was assayed by Particle Counting Assay in the cerebrospinal fluid (CSF) from 26 non-neurological patients, from 190 patients with various neurological disorders and from 84 patients with malignant hemopathies. With a sensitivity limit of 0.5 microgram/l, SP1 was undetectable in normal CSF. High levels were observed in CSF from one pregnant woman with herpetic encephalitis and from another woman with post-puerperal thrombophlebitis as a result of high serum concentrations and leakage of the blood-brain barrier. SP1 was detected at low levels in the CSF from 1 patient out of 5 with Creutzfeldt-Jakob disease and from a patient with Behcet's disease. Seven patients out of 84 with malignant hemopathies presented cerebral involvement; 3 of them had detectable SP1. However, SP1 was also detected in the CSF of 2 patients in apparently complete remission. The determination of SP1 in CSF appears to be of limited value in the diagnosis of neurological disorders and in the early detection of a cerebral localization of malignant hemopathies.
MH Burkitt Lymphoma/cerebrospinal fluid; Female; Human; Leukemia, Lymphocytic/cerebrospinal fluid; Leukemia, Myelocytic, Acute/cerebrospinal fluid; Nervous System Diseases/*cerebrospinal fluid/diagnosis; Pregnancy; Pregnancy Proteins/*cerebrospinal fluid; Pregnancy-Specific beta 1-Glycoprotein/*cerebrospinal fluid; Support, Non-U.S. Gov't
SP englisch
PO Schweiz