NR ADVV
AU Fairbairn,D.W.; Thwaits,R.N.; Holyoak,G.R.; O'Neill,K.L.
TI Spongiform encephalopathies and prions: an overview of pathology and disease mechanisms.
QU FEMS Microbiology Letters 1994 Nov 1; 123(3): 233-9
PT journal article; review; review, tutorial
AB The etiology of spongiform encephalopathies has been sharply contested for decades. At the heart of the issue is the question of disease origin: Are prion disease representative of primary neurodegenerative genetic disorders, or are they bona fide infectious diseases? This article provides a brief outline of the progress made in the elucidation of prion disease mechanisms in the context of pathological support of the 'protein only' hypothesis. The answer to the above question appears to be that spongiform encephalopathies are uniquely both infectious and genetic neurodegenerative diseases.
ZR 24
MH Animal; Disease Models, Animal; Human; Mice; Mice, Transgenic; Prion Diseases/*etiology/pathology/transmission; Prions/chemistry/genetics/*pathogenicity
AD Department of Microbiology, Brigham Young University, Provo, Utah 84602.
SP englisch
PO Niederlande