NR ADWE
AU Farlow,M.; Ghetti,B.; Dlouhy,S.; Giaccone,G.; Bugiani,O.; Tagliavini,F.; Wagner,S.
TI Cerebrospinal fluid levels of amyloid beta-protein precursor are low in Gerstmann-Sträussler-Scheinker disease, Indiana kindred
QU Neurology 1994 Aug; 44(8): 1508-10
PT journal article
AB We studied levels of amyloid beta-protein precursor (beta PP) in CSF from four patients affected with Gerstmann-Sträussler-Scheinker disease and one asymptomatic gene-carrier from an Indiana kindred. Levels of beta PP were decreased in all affected patients with the lowest levels occurring in the clinically most severely affected patients. Correlation of neuropathology with CSF data in three patients suggested that low beta PP in CSF may be associated with beta PP accumulation in neurites surrounding cortical and cerebellar amyloid deposits.
ZR 10
MH Aged; Amyloid beta-Protein Precursor/*cerebrospinal fluid; Brain/pathology; Enzyme-Linked Immunosorbent Assay; Gerstmann-Sträussler-Scheinker Disease/*cerebrospinal fluid/pathology; Human; Indiana; Middle Age; Support, Non-U.S. Gov't; Support, U.S. Gov't, P.H.S.
AD Department of Neurology, Indiana University School of Medicine, Indianapolis 46202-5124.
SP englisch
PO USA