NR ADYN
AU Ferrer,I.; Casas,R.; Rivera,R.
TI Parvalbumin-immunoreactive cortical neurons in Creutzfeldt-Jakob disease
QU Annals of Neurology 1993 Dec; 34(6): 864-6
PT journal article
AB Massive abnormalities of parvalbumin-immunoreactive cortical neurons were observed in the cerebral biopsy samples of 3 patients with Creutzfeldt-Jakob disease. Immunoreactive cells had reduced and short, often fragmented, dendrites, and large numbers of dendritic varicosities were observed. Since parvalbumin-immunoreactive neurons are the most important inhibitory cells in the cerebral cortex, the damage to these neurons may account, in part, for the impaired cortical function, and may play a role in the appearance of myoclonus and electroencephalographic patterns in patients with Creutzfeldt-Jakob disease.
MH Cerebral Cortex/*pathology; Creutzfeldt-Jakob Syndrome/*pathology; Female; Human; Immunohistochemistry; Male; Middle Age; Neurons/*pathology; Parvalbumins/immunology/*metabolism; Support, Non-U.S. Gov't
AD Unidad de Neuropatologia, Hospital Principes de Espana, Universidad de Barcelona.
SP englisch
PO USA