NR AEAY
AU Fishbein,L.
TI Transmissible spongiform encephalopathies, hypotheses and food safety: an overview.
QU Science of the Total Environment 1998 Jun 30; 217(1-2): 71-82
PT journal article; review; review, tutorial
AB The transmissible spongiform encephalopathies (TSEs) (in both humans and animals) have been reviewed with the principal focus on bovine spongiform encephalopathy (BSE), its recent outbreak amongst cattle in the UK ('mad cow disease') and its sequelae. The possible reasons for this outbreak are discussed as well as a number of hypotheses reviewed for TSEs (e.g. prions, organophosphates, etc.) and current measures attendant with food safety and surveillance taken in the European Union. It is generally accepted that the combined weight of all the evidence to date supports the conclusion that the new rare but lethal variant Creutzfeldt-Jakob Disease (vCJD) is the human counterpart of the aetiological agent BSE and that eating meat from the infected animals is probably to blame for 24 deaths (23 in the UK and one in France) to date from vCJD. Considerable evidence from biochemical, immunologic, pathologic and genetic studies strongly suggests that PrPsc is the major component of the transmissible prion particle responsible for the rare fatal brain TSE diseases.
ZR 89
MH Animal; Cattle; Creutzfeldt-Jakob Syndrome/etiology/*transmission; *Disease Outbreaks; *Disease Transmission; Encephalopathy, Bovine Spongiform/physiopathology/*transmission; *Food Contamination; Food Supply/*standards; France; Great Britain; Human; Prions
SP englisch
PO Niederlande