NR AEBQ
AU Foley,G.L.; Zachary,J.F.
TI Rabies-induced spongiform change and encephalitis in a heifer
QU Veterinary Pathology 1995 May; 32(3): 309-11
PT journal article
AB A 1-year-old mixed breed heifer was presented to the Veterinary Medical Teaching Hospital at the University of Illinois with a 3-day history of abnormal mentation and aggressive behavior. Based on the history and clinical examination, euthanasia and necropsy were recommended. The differential diagnosis included rabies, pseudorabies, and a brain abscess. The brain was removed within 60 minutes of death, and the section submitted for fluorescent antibody testing was positive for rabies virus antigen. Residual brain tissue was immersion fixed in 10% neutral buffered formalin. Histologic examination revealed a marked perivascular and meningeal lymphocytic meningoencephalitis and locally extensive spongiform change of the gray matter affecting the neuropil and neuron cell bodies. The most severely affected regions with spongiform change were the thalamus and cerebral cortex. No Negri bodies were found in any sections. Since the outbreak of bovine spongiform encephalopathy (BSE) in the United Kingdom, there has been an increased surveillance of bovine neurologic cases in an effort to assess if BSE has occurred in the USA. In areas where rabies virus is endemic, rabies should be included as a possible differential diagnosis in cases of spongiform changes of the central nervous system.
IN In Illinois (USA) wurde eine junge Kuh getötet, die an der Tollwut litt. Das Gehirn war schwammartig degeneriert. Wohl weil BSE in den USA offenbar immer noch höchstens sehr selten vorkommt, halten die Autoren die Tollwut-Erreger für die Ursache dieser Veränderungen. Beweise legen sie dafür aber nicht vor.
MH Animal; Brain/*pathology; Case Report; Cattle; Cattle Diseases/*diagnosis/pathology; Diagnosis, Differential; Encephalitis/diagnosis/pathology/*veterinary; Encephalopathy, Bovine Spongiform/pathology; Female; Fluorescent Antibody Technique; Rabies/diagnosis/pathology/*veterinary; Thalamus/pathology
AD Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Illinois, Urbana 61801, USA
SP englisch
PO USA