NR AECT
AU Foster,J.D.; Hunter,N.
TI Transmissible spongiform encephalopathies: transmission, mechanism of disease, and persistence.
QU Current Opinion in Microbiology 1998 Aug; 1(4): 442-7
PT journal article; review; review, tutorial
AB Prion protein is central to the control of development of all transmissible spongiform encephalopathies. Controversy exists as to whether the protein itself is responsible for disease manifestation, in one of perhaps several isoforms, or whether an additional informational molecule must be involved in conjunction with the protein. Recent studies have been trying to resolve these issues.
ZR 52
MH Animal; Cattle; Creutzfeldt-Jakob Syndrome/etiology/transmission; Encephalopathy, Bovine Spongiform/etiology/transmission; Human; Models, Biological; Prion Diseases/*etiology/*transmission; Prions/metabolism; Scrapie/etiology/transmission; Sheep
AD Institute for Animal Health Biotechnology and Biological Sciences, Neuropathogenesis Unit, Ogston Building, West Mains Road, Edinburgh EH93JF, UK. Jim.Foster@bbsrc.ac.uk
SP englisch
PO England