NR AECU
AU Foster,J.D.; Parnham,D.W.; Hunter,N.; Bruce,M.E.
TI Distribution of the prion protein in sheep terminally affected with BSE following experimental oral transmission
QU Journal of General Virology 2001 Oct; 82(10): 2319-26
PT journal article
AB This study has examined the distribution of PrPsc in sheep by immunocytochemistry of tissues recovered from terminally affected animals following their experimental infection by the oral route with BSE. Despite a wide range of incubation period lengths, affected sheep showed a similar distribution of high levels of PrPsc throughout the central nervous system. PrPsc was also found in the lymphoid system, including parts of the digestive tract, and some components of the peripheral nervous system. These abundant PrPsc deposits in sheep in regions outside the central nervous system are in direct contrast with cattle infected with BSE, which show barely detectable levels of PrPsc in peripheral tissues. A number of genetically susceptible, challenged animals appear to have survived.
IN Während die Infektiosität in BSE-kranken Rindern fast ausschließlich auf das Zentralnervensystem konzentriert ist, fand man in durch orale Inokulation BSE-infizierten Schafen immunhistochemisch PrPsc nicht nur im Zentralnervensystem, sondern auch in lymphoiden Geweben und Teilen des peripheren Nervensystems.
MH Animal; Cattle; Encephalopathy, Bovine Spongiform/*metabolism/transmission; Genotype; Immunohistochemistry; Prions/*analysis/genetics; Sheep; Sheep Diseases/*metabolism; Support, Non-U.S. Gov't
AD James D. Foster (jim.foster@bbsrc.ac.uk), Nora Hunter (nora.hunter@bbsrc.ac.uk), Moira E. Bruce (moira.bruce@bbsrc.ac.uk), Institute for Animal Health, BBSRC and MRC, Neuropathogenesis Unit, Ogston Building, West Mains Road, Edinburgh EH9 3JF, Scotland, UK
SP englisch
PO England