NR AEDD
AU Foster,J.D.; Scott,J.R.; Fraser,H.
TI The use of monosodium glutamate in identifying neuronal populations in mice infected with scrapie
QU Neuropathology and Applied Neurobiology 1990 Oct; 16(5): 423-30
PT journal article
AB The excitatory amino-acid, monosodium glutamate, which causes degeneration in the retinal ganglion cells in neonatal mice, was used to investigate the transport of scrapie within optic nerve axons. In treated mice, there was prolongation of the incubation period following intraocular infection with the ME7 strain of scrapie, and a decrease in the severity of retinopathy after intracerebral infection with the 79A strain. These data confirm that scrapie infection spreads along neural pathways, and demonstrate the potential use of selective neurotoxins to study pathogenesis.
MH Animal; Animals, Newborn; Female; Ganglia/pathology; Mice; Mice, Inbred Strains; Neurons/*ultrastructure; Optic Nerve/pathology; Photoreceptors/physiology; Retina/pathology; Scrapie/*pathology; Sodium Glutamate/*diagnostic use
AD AFRC and MRC Neuropathogenesis Unit, Edinburgh.
SP englisch
PO England