NR AEDH
AU Foster,J.D.; Davies,D.J.; Fraser,H.
TI Primary retinopathy in scrapie in mice deprived of light
QU Neuroscience Letters 1986 Dec 3; 72(1): 111-4
PT journal article
AB Rodents infected with some strains of scrapie develop a severe retinopathy in which the photoreceptor cells are destroyed. The possibility that this results from light-induced damage as a secondary consequence of the disease was tested by maintaining scrapie-infected albino mice in total darkness. Photoreceptor loss occurred in terminal scrapie-infected mice maintained in both total darkness and in normal lighting conditions establishing that the retinopathy is a primary lesion with this strain of scrapie agent.
MH Animal; Female; Light/*adverse effects; Mice; Mice, Inbred Strains; Retina/pathology; Retinal Degeneration/*etiology/pathology; Scrapie/*complications/pathology
SP englisch
PO Niederlande