NR AEFE
AU Fraser,J.R.; Brown,J.M.; Bruce,M.E.; Jeffrey,M.J.
TI Scrapie-induced neuron loss is reduced by treatment with basic fibroblast growth factor
QU Neuroreport 1997 Jul 7; 8(9-10): 2405-9
PT journal article
AB Neuron loss can be a prominent feature of the pathology of transmissible spongiform encephalopathies (TSEs); recent evidence indicates that this loss occurs through apoptosis. Growth factor treatment of other neurodegenerative diseases has been shown to protect neurons destined for apoptosis, and several types of experimental retinopathy have been successfully treated with basic fibroblast growth factor (bFGF). In a murine scrapie model which develops a severe loss of photoreceptors, we administered a single intravitreal injection of bFGF four-fifths of the way through the disease process; this doubled the number of photoreceptors surviving for up to 5 weeks, i.e. to the terminal stages of the disease. This is the first time that a potential late-stage therapy for the TSEs has been demonstrated.
IN Eine Injektion von basischem Fibroblastenwachstumsfaktor in den Augenlinsenglaskörper nach 4/5 der Inkubationszeit bewirkte bei scrapieinfizierten Mäusen, dass nach 5 Wochen noch doppelt so viele Photorezeptoren wie sonst üblich überlebten.
ZR 23
MH Animal; Cell Death/*drug effects; Disease Models, Animal; Fibroblast Growth Factor 2/*pharmacology; Mice; Mice, Inbred C57BL; Neurons/drug effects; Photoreceptors/*drug effects; Retina/*drug effects; Scrapie/*drug therapy/pathology
AD Janet R. Fraser (janet.fraser@bbsrc.ac.uk), John M. Brown, Moira E. Bruce (moira.bruce@bbsrc.ac.uk), Institute for Animal Health, BBSRC and MRC, Neuropathogenesis Unit, Ogston Building, West Mains Road, Edinburgh EH9 3JF, Scotland, UK; Martin J. Jeffrey (m.jeffrey@vla.maff.gov.uk), VLA Lasswade Veterinary Laboratory, Pentlands Science Park, Bush Loan, Penicuik, Edinburgh EH26 OPZ, Scotland, UK
SP englisch
PO England
OR Prion-Krankheiten 3