NR AEFX
AU Frigg,R.; Klein,M.A.; Hegyi,I.; Zinkernagel,R.M.; Aguzzi,A.
TI Scrapie pathogenesis in subclinically infected B-cell-deficient mice
QU Journal of Virology 1999 Nov; 73(11): 9584-8
PT journal article
AB Prion infections can present without clinical manifestations. B-cell deficiency may be a model for subclinical transmissible spongiform encephalopathy, since it protects mice from disease upon intraperitoneal administration of scrapie prions; however, a proportion of B-cell-deficient mice accumulate protease-resistant prion protein in their brains. Here, we have characterized this subclinical disease. In addition, we have studied the possibility that a neurotoxic factor secreted by B cells may contribute to pathogenesis.
IN Mäuse mit defekten B-Zellen werden häufiger nach intraperitonealer Scrapie-Inokulation nicht krank, obwohl sie Infektiosität akkumulieren. Dies nennt man subklinisch im Gegensatz zu präklinisch.
MH Animal; B-Lymphocytes/*immunology; Blotting, Western; Brain/metabolism/*pathology; Endopeptidase K/metabolism; Mice; PrPsc Proteins/analysis/metabolism; Scrapie/immunology/*pathology; Support, Non-U.S. Gov't
AD Institutes of Neuropathology, Department of Pathology, CH-8091 Zürich, Switzerland.
SP englisch
PO USA