NR AEJS
AU Galvez,S.; Masters,C.; Gajdusek,D.C.
TI Descriptive epidemiology of Creutzfeldt-Jakob disease in Chile
QU Archives of Neurology 1980 Jan; 37(1): 11-4
PT journal article
AB Descriptive epidemiological data are presented from a survey of 35 cases of Creutzfeldt-Jakob disease (CJD) that occurred in Chile in the period 1955 to 1977. The average mortality in Chile (0.31 deaths per 1 million) and in urban Santiago (0.73 deaths per 1 million) is compared with data reported from other countries. An increasing incidence in recent years is probably related to a greater awareness of the disease. The familial occurrence of CJD in nine patients from five affected families is described, and its analysis suggests a genetically determined susceptibility with incubation periods of more than 30 years. Horizontal transmission of the disease may have occurred in one patient in whom the disease developed 13 years after the patient married into a family with seven other affected members.
IN In Chile wurden epidemiologisch auswertbare Daten von 35 Creutzfeldt-Jakob-Patienten aus den Jahren 1955-1977 untersucht. Die registrierte CJD-Inzidenz lag in Chile generell bei 0,31, in Santiago aber schon bei 0,73 pro Million Einwohner und Jahr. In einem Fall trat die Creutzfeldt-Jakob-Krankheit bei einer Person ein, die 13 Jahre zuvor in eine Creutzfeldt-Jakob-Familie mit 7 bekannten Fällen hinein geheiratet hatte.
MH Adult; Age Factors; Aged; Chile; Creutzfeldt-Jakob Syndrome/genetics/*mortality; Female; Human; Male; Middle Age; Pedigree; Sex Factors; Socioeconomic Factors
SP englisch
PO USA