NR AELT
AU Gaytan-Garcia,S.; Gilbert,J.J.; Deck,J.H.; Kaufmann,J.C.E.
TI Jakob-Creutzfeldt disease associated with Wernicke encephalopathy
QU Canadian Journal of Neurological Sciences 1988 May; 15(2): 156-60
PT journal article
AB Wernicke disease (WD) is a complication of alcoholism and malnutrition and usually presents acutely and is characterized by disturbances of consciousness, paralysis of the external ocular muscles, and ataxia. The disease results from deficiency of vitamin B 1, or thiamine, an essential coenzyme in intermediate carbohydrate metabolism. On the other hand, Jakob-Creutzfeldt disease (J-C) results from infection with an unconventional agent with a long incubation period and is characterized by a rapidly progressive dementia and histologically by a spongiform encephalopathy associated with neuronal destruction and pronounced astrogliosis. Combination of both diseases has not been reported in the literature previously and their relationship is uncertain. We present 3 cases with this interesting association and consider their relationship.
MH Aged; Case Report; Creutzfeldt-Jakob Syndrome/*complications/pathology; Female; Human; Male; Middle Age; Wernicke Encephalopathy/*complications/pathology
AD University Hospital, Victoria Hospital, London, Ontario, Canada.
SP englisch
PO Kanada