NR AEPH
AU Giraud,P.; Biacabe,A.G.; Chazot,G.; Later,R.; Joyeux,O.; Moene,Y.; Perret-Liaudet,A.
TI Increased Detection of 14-3-3 Protein in Cerebrospinal Fluid in Sporadic Creutzfeldt-Jakob Disease during the Disease Course
QU European Neurology 2002; 48(4): 218-21
PT journal article
AB Diagnosis of Creutzfeldt-Jakob Disease (CJD) is based on neurological signs associated with characteristic electroencephalographic activity or detection of 14-3-3 protein in cerebrospinal fluid. However, the time course of 14-3-3 protein release during sporadic CJD is unknown. We report two observations in which the level of the detected 14-3-3 protein increased significantly with time. These preliminary cases suggest that there may be an increased release of 14-3-3 protein during the course of CJD as already proven for iatrogenic CJD.
AD Centre Hospitalier General d'Annecy, Service de Neurologie A, Annecy, France.
SP englisch
PO Schweiz