NR AESC
AU Goldwater,P.N.; Paton,J.C.
TI Apparent non-involvement of prions in the pathogenesis of spongiform change in HIV-infected brain
QU Journal of Neuropathology and Experimental Neurology 1989 Mar; 48(2): 184-6
PT journal article
AB Characteristic neuropathological white matter changes in the brains of patients dying from the acquired immune deficiency syndrome (AIDS) suggest pathogenetic involvement of either the PrP27-30 gene or a scrapie-related prion; however, proteinase-K resistant scrapie-like proteins could not be detected in brain tissue from AIDS patients.
MH Acquired Immunodeficiency Syndrome/*metabolism; Blotting, Western; *Brain Chemistry; Human; PrP 27-30 Protein; *Prions; Support, Non-U.S. Gov't; Viral Proteins/analysis
AD Department of Microbiology, Adelaide Children's Hospital, South Australia.
SP englisch
PO USA