NR AESV
AU Gonzalo Pascual,I.; Cuadrado Corrales,N.
TI [Immunohistochemistry techniques in prion diseases]
OT Tecnicas de inmunohistoquimica en las enfermedades por priones
QU Revista de Neurologia 2000 Jul 16-31; 31(2): 156-9
PT journal article
AB The prion diseases are characterized by showing a broad spectrum of phenotypes with different clinical and neuropathological presentations. Detection of the prion protein is the marker used as a tool for making the definite diagnosis in these neurodegenerative diseases. Its presence may be detected by immunohistochemical and biochemical techniques. On immunohistochemical studies the prion protein shows three types of staining: as plaques of PrP-amyloid, perivascular and diffuse-synaptic.
MH English Abstract; Human; Immunohistochemistry; Prion Diseases/classification/*metabolism; Prions/*metabolism
AD Banco de Tejidos para Investigacion Neurologica, Facultad de Medicina, Universidad Complutense de Madrid, Espana. igonzalo@lettera.net
SP spanisch
PO Spanien