NR AEUG
AU Grabow,J.D.; Campbell,R.J.; Okazaki,H.; Schut,L.; Zollman,P.E.; Kurland,L.T.
TI A transmissible subacute spongiform encephalopathy in a visitor to the eastern highlands of New Guinea
QU Brain: A Journal of Neurology 1976 Dec; 99(4): 637-58
PT journal article
AB A Caucasian male, clinically ill with a respiratory disease, visited the Eastern Highlands of New Guinea (endemic for kuru in the Fore people) and developed subacute spongiform encephalopathy (Jakob-Creutzfeldt disease) ten weeks later, from which he subsequently died. Brain material was inoculated intracranially into squirrel monkeys, and several of them developed a spongiform encephalopathy. Monkeys that received control material (normal brain) were normal. Electronmicroscopic features in affected brain tissue are described, and the question of a relationship between Jakob-Creutzfeldt disease and kuru is considered.
MH Animal; Brain Diseases/*microbiology/physiopathology/transmission; Case Report; Cerebral Cortex/pathology; Creutzfeldt-Jakob Syndrome/microbiology; Electroencephalography; Haplorhini; Human; Kuru/microbiology; Male; Middle Age; New Guinea; Saimiri; Slow Virus Diseases/*microbiology/physiopathology/transmission
SP englisch
PO England