NR AEWW
AU Grignon,Y.; Colle,M.A.; Hauw,J.J.
TI [Cerebral amyloidosis]
OT Amylose cerebrale
QU Revue du Praticien 1997 Oct 15; 47(16): 1793-7
PT journal article; review; review, tutorial
AB Cerebral amyloidoses affects only the central nervous system, with rare exceptions. Most of them are related to A beta deposits. They usually occur in the absence of genetic defect in the precursor of A beta. The prevalence and density of A beta deposits increase during the aging process, and in Alzheimer's disease. This A beta amyloidosis has never been transmitted. In contrast, PrPres occurs as a sporadic or genetic event, and induces transmissible amyloidoses (Creutzfeldt-Jakob's disease and other disorders related to non conventional agents). PrPres may be the infectious agent itself (prion hypothesis). Other proteins are rarely responsible for cerebral amyloidoses. The fascinating hypothesis that a common mechanism would be acting in all cerebral amyloidoses has not yet been confirmed.
ZR 12
MH Amyloid Neuropathies/*chemically induced/diagnosis; Amyloid beta-Protein/metabolism; Cerebral Amyloid Angiopathy/*diagnosis/metabolism; English Abstract; Human; Prions/adverse effects
AD Laboratoire de neuropathologie, Raymond-Escourolle, Universite Pierre et Marie Curie (Paris VI), INSERM U 360, Association Claude-Bernard, Paris.
SP französisch
PO Frankreich