NR AEYJ
AU Guiroy,D.C.; Liberski,P.P.; Williams,E.S.; Gajdusek,D.C.
TI Electron microscopic findings in brain of Rocky Mountain elk with chronic wasting disease
QU Folia Neuropathologica 1994; 32(3): 171-3
PT journal article
AB We report here the electron microscopic findings in brain of Rocky Mountain elk with chronic wasting disease (CDW), a progressive and fatal neurological disorder of wild ruminants characterized neuropathologically by intraneuronal vacuolation, spongiform change of the neuropil and astrocytic hypertrophy and hyperplasia. Ultrastructural findings included membrane-bound vacuoles in neuronal elements, increased number of glial filaments, dystrophic neurites, numerous neuritic plaques, Hirano bodies and perikaryal inclusion bodies. Similar findings have been observed in CWD-affected mule deer, as well as in bovine spongiform encephalopathy, and in natural and experimental scrapie and Creutzfeldt-Jakob disease indicating a common etiopathogenesis.
MH Animal; Brain/*physiopathology/*ultrastructure; Brain Diseases/*physiopathology; *Chronic Disease; Creutzfeldt-Jakob Syndrome/physiopathology; Encephalopathy, Bovine Spongiform/physiopathology; Female; Inclusion Bodies; *Microscopy, Electron; Scrapie/physiopathology; Support, Non-U.S. Gov't
AD Department of Neurology, University of Düsseldorf, Germany.
SP englisch
PO Polen