NR AFCU
AU Hardy,J.
TI Pathways to primary neurodegenerative disease
QU Annals of the New York Academy of Sciences 2000; 924: 29-34
PT journal article; review; review, tutorial
AB Genetic analysis has revealed the pathogenic lesions that cause autosomal dominant Alzheimer's disease, prion disease, and some forms of Parkinson's disease. Molecular biological experiments based on these genetic findings allow a hypothesis to be configured linking these and the other diseases in which tangles or Lewy bodies are a pathological feature. In this article, this hypothesis is presented in the context of deriving curative treatments for these disorders.
ZR 19
MH Alzheimer Disease/genetics/*pathology; Brain/*pathology; Human; Parkinson Disease/genetics/pathology; Prion Diseases/genetics/pathology
AD Mayo Clinic Jacksonville, 4500 San Pablo Road, Jacksonville, Florida 32224, USA. hardy@mayo.edu
SP englisch
PO USA