NR AFDN
AU Harrington,M.G.; Merril,C.R.; Torrey,E.F.
TI Differences in cerebrospinal fluid proteins between patients with schizophrenia and normal persons
QU Clinical Chemistry 1985 May; 31(5): 722-6
PT journal article
AB A survey of cerebrospinal fluid (CSF) proteins from normal persons and patients with schizophrenia reveals differences between the two populations. Computer-assisted densitometry of 68 proteins, resolved by two-dimensional electrophoresis and made visible by silver staining, shows six changes. Compared with their occurrence in the normal group, two proteins are increased in the schizophrenic patients by 22% and 27%, while four proteins are decreased by 29%, 46%, 20%, and 37% (p less than 0.005). Furthermore, two additional 40 000-Da proteins are found in CSF from 31.5% of the schizophrenic patients. Although these disease-associated proteins have not yet been found in 12 other neurological and psychiatric conditions, they have been found in patients with herpes simplex encephalitis (90%), Creutzfeldt-Jakob disease (67%), multiple sclerosis (13%), Parkinson's disease (12%), and a single case of Guillain-Barre syndrome. These two 40 000-Da proteins have never been found in CSF from any of 99 normal persons.
MH Adolescent; Adult; Aged; Cerebrospinal Fluid Proteins/*isolation & purification; Computers; Densitometry; Electrophoresis; Female; Human; Male; Middle Age; Schizophrenia/*cerebrospinal fluid; Support, Non-U.S. Gov't
SP englisch
PO USA