NR AFEK
AU Harrison,P.M.; Bamborough,P.; Daggett,V.; Prusiner,S.B.; Cohen,F.E.
TI The prion folding problem
QU Current Opinion in Structural Biology 1997 Feb; 7(1): 53-9
PT journal article; review; review, tutorial
AB Prion diseases are neurodegenerative disorders in which dramatic conformational change in the structure of the prion protein is the fundamental event. This structural transition involves the loss of substantial alpha-helical content and the acquisition of beta-sheet structure. A convergence of recent biological and structural studies argues that the mechanism underlying the prion diseases is truly unprecedented.
ZR 51
MH Biopolymers; Magnetic Resonance Spectroscopy; Prions/*chemistry; *Protein Folding; Protein Structure, Tertiary
AD University of California, Box Number 450, San Francisco, CA-94143, USA
SP englisch
PO England