NR AFFT
AU Hauw,J.J.; Naccache,P.Y.; Seilhean,D.; Camilleri,S.; Mokhtari,K.; Duyckaerts,C.
TI [Neuropathology of non conventional infectious agents or prions]
OT Neuropathologie des agents infectieux non conventionnels ou prions
QU Pathologie Biologie 1995 Jan; 43(1): 43-52
PT journal article; review; review, tutorial
AB The neuropathological diagnosis of infections by non conventional agents relies on four lesions: astrocytic gliosis (cell hypertrophy and proliferation) usually contrasting with absent mononuclear cell infiltrates (lymphocytes, monocytes-macrophages, and/or microglia) revealed by conventional techniques, and neuronal loss in the most affected areas are little specific findings. Amyloid plaques that are inconstantly found, and spongiosis of gray matter, a characteristic and very frequent finding, are most specific. PrP immunohistochemistry brings additional data. The main diagnostic difficulties are emphasized, and guidelines for Pathological studies are recalled.
ZR 99
MH Animal; Cattle; Creutzfeldt-Jakob Syndrome/*diagnosis/pathology; Diagnosis, Differential; Encephalopathy, Bovine Spongiform/*diagnosis/pathology; English Abstract; Gerstmann-Sträussler-Scheinker Disease/*diagnosis/pathology; Human; Kuru/*diagnosis/pathology; Prion Diseases/*diagnosis/pathology
AD Laboratoire de Neuropathologie R. Escourolle, Hopital de la Salpetriere, Universite Paris VI, INSERM U 360, Association Claude Bernard, France.
SP französisch
PO Frankreich