NR AFMU
AU Hope,J.
TI Prions and neurodegenerative diseases
QU Current Opinion in Genetics and Development 2000 Oct; 10(5): 568-74
PT journal article; review; review, tutorial
AB The long-term, progressive decay of the central nervous system typifies prion diseases, a group of rare, transmissible maladies affecting humans, sheep, cattle and some other types of mammal. Little is known about the early molecular events in its pathogenesis but the diverse roles of PrP, the prion protein, in its destructive action have recently been re-emphasised.
ZR 62
MH Animal; Gene Expression Regulation; Human; Prion Diseases/*genetics; Prions/*genetics
AD Institute for Animal Health, Berkshire RG20 7NN, Compton, UK. james.hope@bbsrc.ac.uk
SP englisch
PO England