NR AFNZ
AU Horiuchi,M.; Caughey,B.W.
TI Prion protein interconversions and the transmissible spongiform encephalopathies
QU Structure with Folding and Design 1999 Oct 15; 7(10): R231-40
PT journal article; review; review, tutorial
AB Autocatalytic changes in the conformation and aggregation state of prion protein appear to be fundamental to transmissible spongiform encephalopathies or prion diseases. Here we review the considerable progress that has been made in describing the normal properties of prion protein and the changes that occur during these devastating neurodegenerative diseases.
ZR 96
MH Animal; Dimerization; Human; Macromolecular Systems; Models, Molecular; Mutation; PrPsc Proteins/chemistry/genetics/metabolism; Prion Diseases/genetics/*metabolism; Prions/*chemistry/genetics/metabolism; Protein Conformation; Protein Folding; Protein Structure, Quaternary
AD Rocky Mountain Laboratories, NIAID, NIH Hamilton, Montana 59840, USA
SP englisch
PO England