NR AFUD
AU Ingelsson,M.; Hyman,B.T.
TI Disordered proteins in dementia
QU Annals of Medicine 2002; 34(4): 259-71
PT journal article
AB Aggregates of dysfunctional proteins and peptides in or between brain neurons are key neuropathological features of dementia and are believed to directly cause or substantially contribute to the development of these diseases. Fundamental parts of the mechanisms underlying the dysregulation of proteins in Alzheimer's disease, frontotemporal dementia, prion diseases and other dementing disorders are now well characterized, mainly due to the discovery of genes causing dominantly inherited disease forms (Table 1). As of today, no efficient pharmacotherapies are available, but new insights into the underlying molecular mechanisms are providing strategies to prevent or even cure these devastating disorders.
AD Harvard Medical School, Massachusetts General Hospital, Charlestown 02129, USA
SP englisch
PO Schweden