NR AFUN
AU Inoue,T.
TI [The use of biotechnological recombinant-mice in biological safety research]
QU Eisei Shikenjo Hokoku. Bulletin of National Institute of Hygienic Sciences 1996(114): 1-12
PT journal article; review; review, tutorial
AB Number of transgenic and knock-out mice increased rapidly during the last decade. This review article describes a potential usefulness of transgenic and knock-out mice for biological safety research with respect to each toxicological category for safety evaluations, such as studies for carcinogenicity, general toxicology, genotoxicologic testing, and immuno-toxicological evaluations. In the carcinogenicity, a possible model required for a short-term study in carcinogenicity was discussed. Further, a couple of future subjects were focused specifically on the biotechnology-derived pharmaceuticals and the biotechnical recombinant-mice as a second generation, i.e. experimental mice with double or multiple gene-recombination. Those usefulnesses were also introduced briefly. Establishing the biotechnical recombinant-mice for each safety testing contributes not only to simplify and qualify the on-going evaluation system, but also to the traditional animal studies to be re-evaluated, so that the solutions may lead them to a future in vitro-alternative system much smoothly. For general references, historical reviews on the biotechnical recombination in experimental animals were also briefly introduced to elucidate a new broad area in developmental biology.
ZR 97
MH Animal; Carcinogenicity Tests; English Abstract; Gene Deletion; Genes, myc; Genes, p53; Genes, ras; *Genetic Engineering; Human; Mice; *Mice, Knockout/genetics; *Mice, Transgenic/genetics; Prions; Recombination, Genetic; Toxicity Tests; Transduction, Genetic
SP japanisch
PO Japan