NR AFYH
AU Jamrozik,Z.; Przybylowski,T.; Zakrzewska-Pniewska,B.; Rafalowska,J.
TI Obstructive sleep apnea syndrome in patient with Creutzfeldt-Jakob disease. Clinical and morphological report.
QU Folia Neuropathologica 1997; 35(3): 149-54
PT journal article
AB We report a case of Creutzfeldt-Jakob disease (CJD) which at the beginning of the disease presented clinical syndrome of progressive supranuclear palsy. Rapid intellectual deterioration, supranuclear palsy, postural instability and myoclonic jerks suggested clinical diagnosis of CJD. After five months suffering from the disease patient developed obstructive sleep apnea syndrome (OSAS) confirmed by serial polysomnograms. OSAS is discussed in the context of the localization of histopathological findings and possible involvement of central autonomic structures. The main structures affected by spongiosis and astrogliosis were cortex, thalamus, basal ganglia and midbrain. OSAS was found as another sleep disturbance in CJD apart from insomnia and sleep-wake cycle abnormalities.
MH Brain/pathology; Case Report; Caudate Nucleus/pathology; Cerebral Cortex/pathology; Creutzfeldt-Jakob Syndrome/*complications/diagnosis; Electroencephalography; Fatal Outcome; Female; Human; Magnetic Resonance Imaging; Mesencephalon/pathology; Middle Age; Neurons/pathology; Polysomnography; Putamen/pathology; Sleep Apnea Syndromes/diagnosis/*etiology
AD Department of Neurology, School of Medicine, Warszawa.
SP englisch
PO Polen