NR AGAL
AU Jesionek-Kupnicka,D.; Buczynski,J.; Kordek,R.; Sobow,T.; Kloszewska,I.; Papierz,W.; Liberski,P.P.
TI Programmed cell death (apoptosis) in Alzheimer's disease and Creutzfeldt-Jakob disease
QU Folia Neuropathologica 1997; 35(4): 233-5
PT journal article
AB The aim of our study was the estimation of the apoptosis process using in situ-end labelling of DNA breaks method on paraffin sections in 5 human cases of Alzheimer's disease (AD), 6 of Creutzfeldt-Jakob disease (CJD) and in 25 mice infected experimentally with the Fujisaki strain of CJD, killed sequentially at one-week intervals. The numbers of apoptotic cells in CJD-infected mice in the later stages of the disease and in terminally ill mice were progressively higher that at the early stage of the disease. Further, we found a correlation between the intensity of apoptosis and major lesions hallmark of disease - the intensity of spongiform changes in the cerebral cortex but not in the accumulation of PrP in CJD infected mice. The number of A beta-amyloid plaques in AD was not related to apoptotic index. Our study showed that apoptosis is a very important event in these neurodegenerative diseases and may become a basic mechanism in loss of neurons.
MH Alzheimer Disease/metabolism/*pathology; Amyloid beta-Protein/analysis; Animal; *Apoptosis; Brain/*pathology; Brain Chemistry; Creutzfeldt-Jakob Syndrome/metabolism/*pathology; DNA Fragmentation; Human; In Situ Nick-End Labeling; Mice; Nerve Tissue Proteins/analysis; PrPc Proteins/analysis; Support, Non-U.S. Gov't
AD Laboratory of Tumor Biology, School of Medicine, Lodz.
SP englisch
PO Polen