NR AGES
AU Kapaki,E.; Kilidireas,K.; Paraskevas,G.P.; Michalopoulou,M.; Patsouris,E.
TI Highly increased CSF tau protein and decreased beta-amyloid (1-42) in sporadic CJD: a discrimination from Alzheimer's disease?
QU Journal of Neurology, Neurosurgery and Psychiatry 2001 Sep; 71(3): 401-3
PT journal article; validation studies
AB The aim was to quantify tau protein and beta-amyloid (Abeta42) in the CSF of patients with sporadic Creutzfeldt-Jakob disease (CJD), Alzheimer's disease (AD), and controls. Double sandwich enzyme linked immunosorbent assays (ELISAs) were used for measurements. Tau was increased 58-fold in CJD and 3.5-fold in AD compared with controls, whereas Abeta42 was decreased 0.5-fold in both CJD and AD. A cut off level for tau protein at 2131 pg/ml successfully discriminated CJD from AD (100% specificity and 93% sensitivity). Tau protein concentration in CSF is probably an additional useful marker in differentiating CJD from AD.
MH Aged; Alzheimer Disease/*cerebrospinal fluid/*diagnosis; Amyloid beta-Protein/*cerebrospinal fluid; Analysis of Variance; Biological Markers/*cerebrospinal fluid; Case-Control Studies; Creutzfeldt-Jakob Syndrome/*cerebrospinal fluid/*diagnosis; Diagnosis, Differential; Discriminant Analysis; Enzyme-Linked Immunosorbent Assay/methods/standards; Female; Human; Male; Middle Age; Sensitivity and Specificity; Time Factors; tau Proteins/*cerebrospinal fluid
AD Department of Neurology, Athens National University, Medical School, Aeginition Hospital, 74 Vas Sophias Avenue, 11528 Athens, Greece. ekapaki@mail.uoa.gr
SP englisch
PO England