NR AGHC
AU Kearney,J.N.; Johnson,C.
TI Evaluation of NaOH treatment of human dura mater implants to obviate Creutzfeldt-Jakob disease transmission
QU Biomaterials 1991 May; 12(4): 431-2
PT journal article
AB One of the few disinfectants known to inactivate the causative agent of Creutzfeldt-Jakob Disease is NaOH. In this study, NaOH was evaluated as a possible routine treatment for human dura mater alloimplants. Use of high concentration NaOH (1 M) resulted in protein loss and macroscopic changes to the tissue. Lower concentrations (0.1 M), although exhibiting little direct detrimental effect, greatly increased the susceptibility of the tissue to collagenase digestion. The use of NaOH treated commercial or institutionally prepared human dura mater should be approached with caution.
IN Eventuell vorhandene CJK-Infektiosität von Dura mater ließe sich durch eine Behandlung mit 0,1 M NaOH vermutlich stark reduzieren. Allerdings erhöht sich durch diese Behandlung die Abbaubarkeit des Materials durch Kollagenasen sehr.
MH Creutzfeldt-Jakob Syndrome/*prevention & control; Dura Mater/drug effects/*transplantation; Human; In Vitro; Microbial Collagenase/pharmacology; Sodium Hydroxide/*pharmacology
AD Yorkshire Regional Tissue Bank, Pinderfields General Hospital, Wakefield, UK
SP englisch
PO England