NR AGIU
AU Kim,H.C.; Chang,K.H.; Song,I.C.; Lee,S.H.; Kwon,B.J.; Han,M.H.; Kim,S.Y.
TI Diffusion-weighted MR imaging in biopsy-proven Creutzfeldt-Jakob disease
QU Korean Journal of Radiology (Official Journal of the Korean Radiological Society) 2001 Oct-Dec; 2(4): 192-6
PT journal article
AB OBJECTIVE: To compare conventional and diffusion-weighted MR imaging in terms of their depiction of the abnormalities occurring in Creutzfeldt-Jakob disease. MATERIALS AND METHODS: We retrospectively analyzed the findings of conventional (T2-weighted and fluid-attenuated inversion recovery) and diffusion-weighted MR imaging in four patients with biopsy-proven Creutzfeldt-Jakob disease. The signal intensity of the lesion was classified by visual assessment as markedly high, slightly high, or isointense, relative to normal brain parenchyma. RESULTS: Both conventional and diffusion-weighted MR images demonstrated bilateral high signal intensity in the basal ganglia in all four patients. Cortical lesions were observed on diffusion-weighted MR images in all four, and on fluid-attenuated inversion recovery MR images in one, but in no patient on T2-weighted images. Conventional MR images showed slightly high signal intensity in all lesions, while diffusion-weighted images showed markedly high signal intensity in most. CONCLUSION: Diffusion-weighted MR imaging is more sensitive than its conventional counterpart in the depiction of Creutzfeldt-Jakob disease, and permits better detection of the lesion in both the cerebral cortices and basal ganglia.
MH Adult; Aged; Biopsy; Comparative Study; Creutzfeldt-Jakob Syndrome/diagnosis/*pathology; Female; Human; Magnetic Resonance Imaging/*methods; Male; Middle Age; Retrospective Studies; Sensitivity and Specificity; Support, Non-U.S. Gov't
AD Department of Radiology, Seoul National University College of Medicine, Korea.
SP englisch
PO Korea