NR AGKT
AU Kimberlin,R.H.; Walker,C.A.
TI Pathogenesis of scrapie: agent multiplication in brain at the first and second passage of hamster scrapie in mice.
QU Journal of General Virology 1979 Jan; 42(1): 107-17
PT journal article
AB The intracerebral (i.c.) injection of mice with a particular source of hamster passaged scrapie produced disease after an incubation period of 325 +/- 6 days (mean +/- s.e.). The incubation period at the second i.e. passage in mice was reduced to 149 +/- 2 days. Studies were made of the dynamics of agent replication at 1st and 2nd passages in mice. At first passage, there was a 'zero phase' lasting about 175 days, when no infectious agent was detected in brain (or spleen), followed by a period of agent replication which lasted 150 days. At second passage, there was no significant 'zero phase' and agent replication occupied the whole of the incubation period. The occurrence of a 'zero phase' on interspecies passage of scrapie is discussed in relation to other reports of a 'zero phase' in mouse passaged scrapie.
MH Animal; Brain/microbiology; Female; Hamsters; Male; Mice; Prions/*growth & development; Scrapie/*microbiology/transmission; Sheep; Species Specificity; Spleen/microbiology; Time Factors
SP englisch
PO England