NR AGKX
AU Kimberlin,R.H.; Millson,G.C.
TI The effects of cuprizone toxicity on the incubation period of scrapie in mice
QU Journal of Comparative Pathology 1976 Jul; 86(3): 489-96
PT journal article
AB Relatively short periods of cuprizone toxicity were induced in mice at selected times in the incubation period of "Chandler" scrapie. Toxicity induced at the time of i.c. and i.p. infection produced effects on the length of incubation period and on the number of mice surviving low doses of scrapie agent. However, these effects were complex and suggested that cuprizone could both increase and decrease the apparent efficiency of infection depending on factors which are difficult to control. Previous studies have shown that cuprizone can induce biochemical and histological lesions in brain similar to those found in "Chandler" scrapie. There was no evidence that the incubation period of scrapie could be shortened by using cuprizone to induce scrapie-like lesions 4 to 6 weeks before they would normally have occurred. These findings suggest that the occurrence of gliosis and astrocyte hypertrophy and the development of many biochemical changes in brain are not of fundamental importance to the development of scrapie.
MH Animal; Brain/pathology; Brain Diseases/chemically induced/*pathology; Cuprizone/*toxicity; Cyclohexanes/*toxicity; Female; Mice; Prions/*growth & development; Scrapie/*pathology; Sheep; Time Factors
AD A.R.C. Institute for Research on Animal Diseases, Compton, Newbury, Berkshire, UK
SP englisch
PO England