NR AGLG
AU Kimberlin,R.H.; Millson,G.C.; Bountiff,L.; Collis,S.C.
TI A comparison of the biochemical changes induced in mouse brain cuprizone toxicity and by scrapie infection
QU Journal of Comparative Pathology 1974 Apr; 84(2): 263-70
PT journal article
AB Studies were made of the activity of acid deoxyribonuclease and eleven glycoside hydrolases, and the rate of incorporation of DNA and glycoprotein precursors in the brains of mice fed on a diet containing 0.5 per cent. cuprizone (biscyclohexanoneoxaldihydrazone) for up to 16 weeks. The profile of changes observed was very similar to that found in the brains of mice infected with the Chandler strain of scrapie agent. The biochemical lesions of cuprizone toxicity in brain could be reversed by withdrawing cuprizone from the diet. It is concluded that many of the biochemical changes seen in Chandler scrapie are not specific for the disease and that cuprizone toxicity may be a useful control for certain types of scrapie experiment.
MH Animal; Body Weight; Brain/drug effects/*metabolism; Carbon Radioisotopes; Cyclohexanes/*toxicity; Deoxyribonucleases/metabolism; Fucose/metabolism; Galactosidases/metabolism; Glucosaminidase/metabolism; Glucuronidase/metabolism; Glycoside Hydrolases/metabolism; Hydrazones/toxicity; Hydrogen-Ion Concentration; Mice; Neuroglia/metabolism; Organ Weight; Scrapie/*metabolism; Sheep; Thymidine/metabolism; Tritium
AD Institute for Research on Animal Diseases, Compton, Newbury, Berkshire, UK
SP englisch
PO England