NR AGLP
AU Kimberlin,R.H.; Millson,G.C.
TI Some biochemical aspects of mouse scrapie
QU Journal of Comparative Pathology 1967 Oct; 77(4): 359-66
PT journal article
AB A slow progressive decrease in brain weight occurred in scrapie affected mice starting about 40 to 50 days after inoculation. Just before the first clinical signs of scrapie appeared this process was greatly accelerated and was accompanied by a decrease in total body weight. An analysis of the water, protein, lipid, DNA and RNA content of control and scrapie affected mouse brains suggests that there is no apparent change in cell numbers and that an overall decrease in the size of brain cells takes place in clinically affected mice, amounting to about 10 to 20 per cent. Since the total amount of RNA per cell is substantially unchanged in scrapie, the reduced cell size results in an increased RNA concentration of about 10 to 20 per cent. The respiratory activity of brain homogenates from clinically affected scrapie mice decreased in parallel with the reduced cell size, but was not otherwise impaired.
MH Animal; Body Weight; Brain/pathology; *Brain Chemistry; DNA/*metabolism; Lipids/*metabolism; Male; Mice; Nerve Tissue Proteins/*metabolism; Organ Weight; RNA/*metabolism; Scrapie/*metabolism/pathology; Sheep; Water/analysis; Water-Electrolyte Balance
AD Institute for Research on Animal Diseases, Compton, Newbury, Berkshire, UK
SP englisch
PO England