NR AGLR
AU Kimura,K.; Nonaka,A.; Tashiro,H.; Yaginuma,M.; Shimokawa,R.; Okeda,R.; Yamada,M.
TI Atypical form of dural graft associated Creutzfeldt-Jakob disease: report of a postmortem case with review of the literature.
QU Journal of Neurology, Neurosurgery and Psychiatry 2001 May; 70(5): 696-9
PT journal article
AB A postmortem case of an atypical form of dural graft associated Creutzfeldt-Jakob disease (CJD) is described. A 42 year old man developed progressive spastic paresis 163 months after a cadaveric dura mater graft. He presented with no myoclonus and very late occurrence of periodic synchronous discharges on EEG. The prion protein (PrP) gene was homozygous for methionine at the polymorphic codon 129. Neuropathological examination disclosed plaque-like PrP deposits with atypical distribution of synaptic PrP accumulations in the brain. This patient represents an atypical form of dural graft associated CJD characterised by unusual clinicopathological features.
MH Adult; Brain/*pathology; Case Report; Creutzfeldt-Jakob Syndrome/*etiology/*pathology; Dura Mater/*pathology/*transplantation; Human; Male; Pituitary Neoplasms/surgery; Support, Non-U.S. Gov't; Transplants/*adverse effects
AD Department of Infectious Diseases, Tokyo Metropolitan Bokutoh General Hospital, Tokyo, Japan.
SP englisch
PO England