NR AGOU
AU Klöppel,S.; Pirker,W.; Brücke,T.; Kovacs,G.G.; Almer,G.
TI Beta-CIT SPECT demonstrates reduced availability of serotonin transporters in patients with Fatal Familial Insomnia
QU Journal of Neural Transmission 2002 Jul; 109(7-8): 1105-10
PT journal article
AB Fatal familial insomnia (FFI) is a rare hereditary human prion disease with unique clinical features including progressive sleep impairment and autonomic dysfunction. The serotonergic system is considered to be involved in the regulation of the sleep-wake cycle. In this study we demonstrate a reduced availability of serotonin transporters of 57% and 73% respectively in a thalamus-hypothalamus region of two FFI patients examined with beta-CIT SPECT as compared to age-expected control values.
MH Adult; Carrier Proteins/*metabolism; Case Report; Cerebellum/metabolism; *Cocaine/analogs & derivatives; Corpus Striatum/metabolism; Human; Hypothalamus/metabolism; Male; Membrane Glycoproteins/*metabolism; Prion Diseases/*metabolism/*radionuclide imaging; *Radiopharmaceuticals; Reference Values; Support, Non-U.S. Gov't; Thalamus/metabolism; Tissue Distribution; *Tomography, Emission-Computed, Single-Photon
AD Institute of Neurology, University of Vienna, Wahringer Gürtel 18-20, A-1090 Vienna, Austria.
SP englisch
PO Österreich