NR AGTG
AU Kovacs,G.G.; Budka,H.
TI Aging, the brain and human prion disease
QU Experimental Gerontology 2002 Apr; 37(4): 603-5
PT journal article
AB Human prion diseases (PrD) preferentially manifest in the elderly. Their neuropathology may coexist with tau immunoreactive neuropil threads, neurofibrillary tangles, and beta-amyloid senile plaques, most likely representing an age-related change rather than a pathogenic link with Alzheimer's disease. Cerebrovascular disease with brain infarction, another malady preferring the elderly, is useful to prove the origin of PrD-associated prion protein deposition exclusively from neurons.
MH Aging/*pathology; Alzheimer Disease/pathology; Brain/*pathology; Creutzfeldt-Jakob Syndrome/pathology; Human; Prions/analysis; Support, Non-U.S. Gov't
AD Institute of Neurology, University of Vienna, Austrian Reference Center of Human Prion Diseases, AKH 4J, P.O. Box 48, Wahringer Gürtel 18-20, 1097, Vienna, Austria.
SP englisch
PO England