NR AGTQ
AU Kovanen,J.; Tiilikainen,A.; Haltia,M.
TI Histocompatibility antigens in familial Creutzfeldt-Jakob disease
QU Journal of the Neurological Sciences 1980 Mar; 45(2-3): 317-21
PT journal article
AB Histocompatibility antigens were defined in 25 members of a Finnish family in which Creutzfeldt-Jakob disease (CJD) was diagnosed clinically in 4 cases and neuropathologically in 3 cases; 3 further cases had a history of presenile dementia. 2 HLA haplotypes were defined in 3 patients and deduced in a further 3 cases; only one haplotype could be deduced in 2 patients. CJD was not linked with a single haplotype, but at least 7 out of 8 patients with this disease apparently shared the HLA antigens A28 and B8.
MH Creutzfeldt-Jakob Syndrome/*genetics/immunology; Female; HLA Antigens/*analysis; Human; Male; Pedigree
SP englisch
PO Niederlande