NR AGXJ
AU Kuroda,Y.; Kaneoka,H.; Shibasaki,H.; Kume,S.; Yamaguchi,M.
TI HLA study of Japanese patients with Creutzfeldt-Jakob disease: significant association with HLA-DQw3.
QU Annals of Neurology 1986 Sep; 20(3): 356-9
PT journal article
AB To demonstrate genetic susceptibility to Creutzfeldt-Jakob disease (CJD), 10 Japanese patients with pathologically proved CJD and 6 patients with clinically definite CJD were tissue typed for 48 class I and 14 class II human leukocyte antigen (HLA) specificities. The patients were scattered throughout Japan and there were no consanguineous relationships. Among 62 HLA specificities, HLA-DRw53 and DQw3 were found in all pathologically proved CJD cases. When the frequencies of the HLA antigens in the 16 CJD cases were compared to those of normal Japanese, a highly significant (p less than 0.005) increase was found for HLA-DQw3 in the CJD group. The present findings provide evidence for genetic control of susceptibility to CJD in humans.
MH Aged; Brain/pathology; Creutzfeldt-Jakob Syndrome/*genetics/pathology; Female; HLA-D Antigens/*analysis; HLA-DR Antigens/*analysis; Human; Japan; Male; Middle Age; Support, Non-U.S. Gov't
SP englisch
PO USA